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KMID : 0882420130840020303
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Korean Journal of Medicine
2013 Volume.84 No. 2 p.303 ~ p.307
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A Case of Sunitinib-Associated Thrombotic Thrombocytopenic Purpura
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Kim Eun-Jin
Choi Yun-Mi
Lee Sin-Won
Ha Yeon-Jung
Lee Jae-Lyun
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Abstract
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Thrombotic thrombocytopenic purpura and hemolytic uremic syndrome (TTP-HUS) is an acute condition with abnormalities of multiple organ systems. It is characterized by microangiopathic hemolytic anemia and thrombocytopenia. Several chemotherapeutic agents have been implicated in causing TTP-HUS. We report a case of TTP-HUS during treatment with sunitinib in a patient with metastatic renal cell carcinoma. A 53-year-old woman visited our hospital for fever and cough. She was diagnosed with sunitinib-induced TTP. Discontinuation of sunitinib and plasmapheresis improved her TTP. When she experienced disease progression after a prolonged period without treatment, sorafenib was tried, resulting in a partial response without recurrence of TTP-HUS.
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KEYWORD
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Sunitinib, Thrombotic thrombocytopenic purpura, Hemolytic uremic syndrome
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